Antinociceptive and anti-inflammatory properties of methanol fruit extract of Quercus incana in rat and mice models

Purpose: To investigate the anti-inflammatory and antinociceptive properties of crude methanol fruit extract of Quercus incana (QI), as well as its acute toxicity and phytochemical profile. Methods: Two animal models were used: Wistar rats for carrageenan-induced paw inflammation and Swiss albino mi...

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Bibliographic Details
Published in:Tropical journal of pharmaceutical research 2016-08, Vol.15 (8), p.1691
Main Authors: Saeed, Muhammad, Gul, Farah, Zakiullah, Gilani, Syed Naeemuddin, Ur Rehman, Yaqoob, Khan, Inamullah, Muhammad, Naveed, Khan, Haroon
Format: Article
Language:English
Subjects:
Anti-inflammatory
Antinociceptive
Phytochemical profile
Quercus incana fruit
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Summary:Purpose: To investigate the anti-inflammatory and antinociceptive properties of crude methanol fruit extract of Quercus incana (QI), as well as its acute toxicity and phytochemical profile. Methods: Two animal models were used: Wistar rats for carrageenan-induced paw inflammation and Swiss albino mice for acetic acid-induced writhing test (hot plate method for anti-nociceptive effect). The extract was also subjected to phytochemical screening using standard procedures. Results: The extract showed significant (p < 0.01) anti-inflammatory effect at doses of 50, 100 and 150 mg/kg. It also evoked significant anti-nociceptive activity (both peripheral and central analgesia) at all test doses (25, 50 and 100 mg/kg; p < 0.01). Acute toxicity data revealed that the extract was non-toxic up to a dose of 425 mg/kg, while phytochemical screening indicated the presence of alkaloids, flavonoids, steroids, terpenoids, anthraquinones, tannins, coumarins, reducing sugars and resins. Conclusion: These results suggest that Quercus incana fruit contains compounds with antinociceptive and anti-inflammatory properties.
ISSN:1596-5996
1596-9827
DOI:10.4314/tjpr.v15i8.14