Histopathological changes associated with exposure of some viscerals and testicular tissues to bisephenol A and di(2-ethylhexyl)phthalate

• Published in: Tropical journal of pharmaceutical research 2021-05, Vol.18 (6), p.1213-1218
• Main Authors: Omorodion, Nosa Terry, Atoigwe-Ogeyemhe, Blessing Emosho, Achukwu, Peter Uwadiegwu, Odigie, Efosa Bolaji
• Format: Article
• Language: English
• ISSN: 1596-5996; 1596-9827
• DOI: 10.4314/tjpr.v18i6.10

Purpose: To evaluate the pathological effect associated with the exposure of viscerals and testicular tissues of albino rats to BPA and DEHP. Methods: A total of sixty adult male Wistar rats weighing 200 – 250 g were divided into four (4) groups of 15 rats per cage in a sanitized environment. Group I animals received normal rodent pellet and water and served as untreated group. Thereafter, the rats in the second group (II) were administered 5 mg/kg per day of BPA mixed with rodent pellet orally; group III received 0.5 mg/kg daily dose of DEHP mixed with rodent pellet; while group IV received orally mixture of 0.5 mg/kg of BPA and 0.5 mg/kg DEHP + pelleted rodent feed. The rats were fed and water provided regularly for 30 days; finally, the animals were weighed and sacrificed by cranial dislocation. Result: BPA and DEHP resulted in significant (p < 0.05) weight losses, inflammation and fatty deposits in the liver, degenerated bowman capsule and glomeruli of the kidneys, lung oedema, and deteriorated leydig cells in testes. Conclusion: The results suggest that BPA and DEHP cause significant weight loss and are injurious to the cellular make-up of rat tissues, which may be the same in higher animals.