Effect of the combination of percutaneous transluminal angioplasty and pharmacological thrombolysis on hemodialysis patients

Purpose: To examine the efficacy of percutaneous transluminal angioplasty (PTA), combined withpharmacologic thrombolysis (PT) on thrombosis of autologous arteriovenous fistulas (AVFs),inflammatory factors, and β2 microglobulin (β2-MG) levels in hemodialysis patients.Methods: Seventy-eight patients w...

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Bibliographic Details
Published in:Tropical journal of pharmaceutical research 2022-04, Vol.21 (2), p.409-416
Main Authors: Yang, Liwen, Tang, Fengying, Zhong, Weiqiang
Format: Article
Language:English
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Summary:Purpose: To examine the efficacy of percutaneous transluminal angioplasty (PTA), combined withpharmacologic thrombolysis (PT) on thrombosis of autologous arteriovenous fistulas (AVFs),inflammatory factors, and β2 microglobulin (β2-MG) levels in hemodialysis patients.Methods: Seventy-eight patients with AVF thrombosis allocated randomly into a control group (CG) received PTA, and a study group (SG) received PTA combined with PT (n = 39 in each). The patency, vascular condition, inflammatory factors, viz, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP)), β2-MG levels, vascular-related factors (VEGF-A and MCP-1), complications, and quality of life were determined.Results: At three and six months after surgery, t SG exhibited a higher vascular patency than CG (p
ISSN:1596-5996
1596-9827
DOI:10.4314/tjpr.v21i2.26