Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extract as an inhibitor of α-MSH-mediated melanogenesis in B16F10 mouse melanoma cells

Purpose: To explore the anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extracts (KFFE) in B16F10 mouse melanoma cells.Methods: The anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruit and leaf extracts (KFFE) were assessed u...

Full description

Saved in:
Bibliographic Details
Published in:Tropical journal of pharmaceutical research 2022-06, Vol.21 (6), p.1189-1193
Main Authors: Kim, Ji Hyung, Cha, Hwa Jun
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To explore the anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extracts (KFFE) in B16F10 mouse melanoma cells.Methods: The anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruit and leaf extracts (KFFE) were assessed using melanin contents assay and tyrosinase expression and activity assay in α-MSH-treated B16F10 mouse melanoma cells.Results: The KFFE reduced α-MSH-mediated melanin synthesis in B16F10 mouse melanoma cells, while the tyrosinase mRNA expression was down-regulated by KFFE in B16F10 mouse melanoma cells (p < 0.05). Furthermore, cellular tyrosinase activity was downregulated by KFFE in B16F10 mouse melanoma cells (p < 0.05).Conclusion: KFFE functions to repress melanin synthesis and thus, can potentially be used as a cosmetic ingredient.
ISSN:1596-5996
1596-9827
DOI:10.4314/tjpr.v21i6.8