Effect of Dentong Xiaoyanling and tinidazole gargle on periodontal parameters in chronic periodontitis, gingival sulcus factor and oral health

• Published in: Tropical journal of pharmaceutical research 2023-11, Vol.22 (11), p.2373-2380
• Main Authors: Xu, Junxian, Lu, Lanfang
• Format: Article
• Language: English
• ISSN: 1596-5996; 1596-9827
• DOI: 10.4314/tjpr.v22i11.18

Purpose: To investigate the effect of concentrated tinidazole gargle combined with Dentong Xiaoyanling on chronic periodontitis. Methods: Ninety-six (96) patients with chronic periodontitis admitted in Chun’an County Traditional Chinese Hospital, Qiandaohu Town, China between January 2021 and December 2022 were randomly divided into two groups: control group (treated with concentrated tinidazole gargle) and study group (treated with concentrated tinidazole gargle + Dentong Xiaoyanling). Periodontal indicators, Gingival sulcus factor (GSF), oral health status, clinical efficacy and adverse reactions were compared between the two groups. Results: There were no significant changes (p > 0.05) in periodontal indicators, GSF or oral health score between the two groups prior to therapy. However, following treatment with Dentong Xiaoyanling and/or concentrated tinidazole gargle, the periodontal indicators, GSF and oral health score of the two groups reduced significantly (p < 0.05), with more pronounced reductions in the study group. Clinical efficacy in the group treated with a combination of concentrated tinidazole gargle and Dentong Xiaoyanling was 91.67 %, which was significantly higher (p < 0.05) than that of control group (75 %). Furthermore, there was no significant difference in the incidence of adverse reactions between the two groups pre- and post-treatment (p > 0.05). Conclusion: Treating chronic periodontitis with concentrated tinidazole gargle + Dentong Xiaoyanling alleviates local inflammatory reaction of gums, enhances recovery from symptoms and improves oral health. Future approaches will require a larger sample size from diverse clinical settings to confirm the effectiveness of this approach.