Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism

We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient&...

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Bibliographic Details
Published in:Dermatology online journal 2017, Vol.23 (7)
Main Authors: Hassoun, Lauren A, Sivamani, Raja K, Sharon, Victoria R, Silverstein, Marc A, Burrall, Barbara A, Tartar, Danielle M
Format: Article
Language:English
Subjects:
Adult
Dermatologic Agents - therapeutic use
Female
Granuloma - drug therapy
Granuloma - etiology
Humans
Interleukin-12 - antagonists & inhibitors
Necrobiosis Lipoidica - complications
Necrobiosis Lipoidica - drug therapy
Necrobiosis Lipoidica - physiopathology
Skin Ulcer - drug therapy
Skin Ulcer - etiology
Ustekinumab - therapeutic use
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Summary:We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient's disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy.
ISSN:1087-2108
1087-2108
DOI:10.5070/D3237035756