Estrogenic and anxiolytic effects of the decoction of stem bark of Khaya anthotheca (Welw.) C.DC (Meliaceae) in ovariectomised Wistar rats

Khaya anthotheca (Welw.) C.DC (Meliaceae) is a plant used in Cameroon to alleviate vaginal dryness in postmenopausal women and is also known to have anxiolytic properties.This work was designed to evaluate estrogen-like effects of this plant on primary estrogens targets of ovariectomized adult rats,...

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Bibliographic Details
Published in:International journal of phytomedicine 2017-07, Vol.9 (2)
Main Authors: Ketcha Wanda, Germain Jean Magloire, ZEMO GAMO, Franklin, DJIOGUE, Sefirin, AWOUNFACK, Charline Florence, NJAMEN, Dieudonne
Format: Article
Language:English
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Summary:Khaya anthotheca (Welw.) C.DC (Meliaceae) is a plant used in Cameroon to alleviate vaginal dryness in postmenopausal women and is also known to have anxiolytic properties.This work was designed to evaluate estrogen-like effects of this plant on primary estrogens targets of ovariectomized adult rats, as well as to evaluate its anxiolytic activities in the elevated plus-maze (EPM) test. In the 3-day uterotrophic assay, the extract increased (p < 0.01) the size of the vaginal epithelia and stimulated the acini differentiation of the mammary gland. In the EPM test, the extract increased the percentage of number of entries (p
ISSN:0975-0185
0975-0185
DOI:10.5138/09750185.2033