Estrogenic and anxiolytic effects of the decoction of stem bark of Khaya anthotheca (Welw.) C.DC (Meliaceae) in ovariectomised Wistar rats

Khaya anthotheca (Welw.) C.DC (Meliaceae) is a plant used in Cameroon to alleviate vaginal dryness in postmenopausal women and is also known to have anxiolytic properties.This work was designed to evaluate estrogen-like effects of this plant on primary estrogens targets of ovariectomized adult rats,...

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Published in:International journal of phytomedicine 2017-07, Vol.9 (2)
Main Authors: Ketcha Wanda, Germain Jean Magloire, ZEMO GAMO, Franklin, DJIOGUE, Sefirin, AWOUNFACK, Charline Florence, NJAMEN, Dieudonne
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container_title International journal of phytomedicine
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creator Ketcha Wanda, Germain Jean Magloire
ZEMO GAMO, Franklin
DJIOGUE, Sefirin
AWOUNFACK, Charline Florence
NJAMEN, Dieudonne
description Khaya anthotheca (Welw.) C.DC (Meliaceae) is a plant used in Cameroon to alleviate vaginal dryness in postmenopausal women and is also known to have anxiolytic properties.This work was designed to evaluate estrogen-like effects of this plant on primary estrogens targets of ovariectomized adult rats, as well as to evaluate its anxiolytic activities in the elevated plus-maze (EPM) test. In the 3-day uterotrophic assay, the extract increased (p < 0.01) the size of the vaginal epithelia and stimulated the acini differentiation of the mammary gland. In the EPM test, the extract increased the percentage of number of entries (p
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title Estrogenic and anxiolytic effects of the decoction of stem bark of Khaya anthotheca (Welw.) C.DC (Meliaceae) in ovariectomised Wistar rats
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