Acute and Repetitive Human Exposure to Isobutane

Eight adult volunteers of both sexes were exposed to isobutane in a controlled-environment chamber for the purpose of monitoring their physiological responses to a series of gas concentrations ranging from 250 to 1,000 ppm. First, the response to exposure periods of 1 min, 2 min, 1 h, 2 h, and 8 h w...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1977-12, Vol.3 (4), p.234-243
Main Authors: STEWART, RICHARD D., HERRMANN, ANTHONY A., BARETTA, EDWARD D., FORSTER, HUBERT V., SIKORA, JEANNE J., NEWTON, PAUL E., SOTO, RICARDO J.
Format: Article
Language:English
Subjects:
Adrenal Cortex - drug effects
Adult
Aerosols
Blood
Butanes - toxicity
Chemical hazards
Clinical Trials as Topic
Double-Blind Method
Electroencephalography
Environment, Controlled
Environmental Exposure
Evoked Potentials
Female
Gases
Heart - drug effects
Humans
Male
Mental concentration
Propane
Propane - toxicity
Propellants
Respiration - drug effects
Respiratory Function Tests
Surveillance
Time Factors
Toxicology
Vision Tests
Vision, Ocular - drug effects
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Summary:Eight adult volunteers of both sexes were exposed to isobutane in a controlled-environment chamber for the purpose of monitoring their physiological responses to a series of gas concentrations ranging from 250 to 1,000 ppm. First, the response to exposure periods of 1 min, 2 min, 1 h, 2 h, and 8 h were studied. There being no untoward responses to these acute exposures, the eight volunteers were exposed repetitively to isobutane at concentrations of 500 ppm, 1, 2 or 8 h per day, five days per week for two weeks. Then exposures to two mixtures of isobutane and propane for 1, 2 or 8 h per day for two days were studied. During the investigation all subjects were kept under comprehensive medical surveillance. No untoward subjective responses or abnormal physiological responses occurred during or following these exposures. Special emphasis was placed on evaluating the cardiac and pulmonary response to these exposures through the use of continuous ECG telemetry and serial computerized spirometrie measurements. The following serial laboratory studies were unaltered by the exposures: complete blood count, urinalysis, serum alkaline phosphatase, SGOT, LDH, serum bilirubin, blood sugar, serum calcium, serum phosphorus, BUN, spontaneous electroencephalogram, visual evoked response, a battery of cognitive tests, and an ACTH stimulation test.
ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.2775