Brain and Blood Lead in Acute Intoxication

Administering lead acetate in drinking water to adult male rats resulted in an elevated lead content in blood and brain during 11 subsequent days. The brain and blood lead contents were proportional to each other although the interdependency changed according to the cumulative dose and equilibration...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1977-06, Vol.3 (2), p.104-107
Main Authors: SAVOLAINEN, HEIKKI, KILPIÖ, JUKKA
Format: Article
Language:English
Subjects:
Animals
Blood
Blood brain barrier
Body weight
Brain
Brain - metabolism
Dosage
Dose-Response Relationship, Drug
Intoxication
Lead
Lead - blood
Lead - metabolism
Lead acetates
Lead Poisoning - metabolism
Linear regression
Male
Potable water
Rats
Time Factors
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Summary:Administering lead acetate in drinking water to adult male rats resulted in an elevated lead content in blood and brain during 11 subsequent days. The brain and blood lead contents were proportional to each other although the interdependency changed according to the cumulative dose and equilibration period. The present data indicate that the permeability of the blood-brain barrier towards inorganic lead may be dose-dependent and saturable with high doses of the metal.
ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.2788