Ocular Surface Disease in Patients under Topical Treatment for Glaucoma

Purpose To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. Methods A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex...

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Bibliographic Details
Published in:European journal of ophthalmology 2017-11, Vol.27 (6), p.694-704
Main Authors: Pérez-Bartolomé, Francisco, Martínez-de-la-Casa, Jose M., Arriola-Villalobos, Pedro, Fernández-Pérez, Cristina, Polo, Vicente, García-Feijoó, Julián
Format: Article
Language:English
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Summary:Purpose To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. Methods A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI). Results Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p
ISSN:1120-6721
1724-6016
DOI:10.5301/ejo.5000977