The evaluation of the inflammatory parameters in the patients with controlled epilepsy versus the patients with resistant epilepsy

• Published in: Neurology Asia 2023-09, Vol.28 (3), p.629-637
• Main Authors: Gesoglu Demir, Tülin, Ethemoglu, Ozlem, Agırcan, Dilek
• Format: Article
• Language: English
• ISSN: 1823-6138
• DOI: 10.54029/2023aej

Objective: This study aims to evaluate the effects of C-reactive protein (CRP), albümin, mean platelet volume (MPV) values and neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLO), MPV/PLT ratio, CRP / Albumin ratios on seizure type and seizure control in epilepsy patients who are refractory or non-refractory to treatments. Methods: The study comprised 43 refractory epilepsy, 64 well-controlled epilepsy patients and control group including 68 healthy individuals. Mean platelet volume (MPV), platelet, CRP, and albumin values of the patients were studied. CRP / albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLO), and the MPV/ PLT ratio were determined. Results: The mean serum CRP and CAO were found to be significantly higher in refractory epilepsy patients compared to well-controlled epilepsy patients and healthy control groups, while MPV and albumin levels were found to be significantly lower. Conclusions: Serum CRP and CAO were found to be significantly higher in refractory epilepsy patients compared to well-controlled epilepsy patients and healthy control groups, while MPV and albumin levels were found to be significantly lower. In addition, this inflammatory activity increases as the frequency of seizures increases and the duration of the disease increases. These findings suggest that increased inflammatory response may affect the patient’s prognosis. In light of these findings, we think new treatment strategies that control the inflammatory response are necessary for patients with refractory epilepsy.