Gene Xpert MTB/RIF assay in patients with clinical suspicion of tuberculous meningitis

Early diagnosis and treatment of tubercular meningitis (TBM) is one of the best predictors of survival. The smear testing of the cerebrospinal fluid (CSF) has a low sensitivity and cultures, though having higher sensitivity, take a long time in TBM diagnosis. The present study was done to evaluate t...

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Bibliographic Details
Published in:Neurology Asia 2023-06, Vol.28 (2), p.291-296
Main Authors: Rathod, Mukesh, Qavi, Abdul, Mittal, Vineeta, Kumar Singh, Ajai, Kumar Maurya, Pradeep, Singh, Arvind, Thacker, Anup, Kulshreshtha, Dinkar
Format: Article
Language:English
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Summary:Early diagnosis and treatment of tubercular meningitis (TBM) is one of the best predictors of survival. The smear testing of the cerebrospinal fluid (CSF) has a low sensitivity and cultures, though having higher sensitivity, take a long time in TBM diagnosis. The present study was done to evaluate the proportion of positive Gene Xpert test, a rapid nucleic acid amplification test, in clinically suspected patients with TBM. The results of Gene Xpert tests were then compared with the culture results. One hundred and fifty prospective patients with a clinical suspicion of TBM were classified as probable or possible TBM and underwent CSF examination for culture and Gene Xpert assay. Out of 124 patients available for statistical evaluation, 52 were in the probable and 72 in possible TBM group. The proportion of patients with Gene Xpert positivity were significantly more in probable compared to possible TBM (63.15% vs 36.85%, p
ISSN:1823-6138
DOI:10.54029/2023ktz