Antitumor effect of trehalose on sarcoma 180 in ICR mice

An antitumor activity on oral administration of trehalose was investigated by using ICR mice implanted Sarcoma 180. After implanting of Sarcoma 180, five kinds of saline solutions containing trehalose (10 to 250 mg/kg) were administrated to mice daily for 10 days. The antitumor effect of trehalose w...

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Bibliographic Details
Published in:Journal of Applied Glycoscience 2005, Vol.52(4), pp.367-368
Main Authors: Ukawa, Y.(Oji Forest and Products Co. Ltd., Tokyo (Japan)), Gu, Y, Ohtsuki, M, Suzuki, I, Hisamatsu, M
Format: Article
Language:English
Subjects:
ADMINISTRACION ORAL
ADMINISTRATION ORALE
antitumor activity
DEFENCE MECHANISMS
DOSAGE EFFECTS
EFECTOS DE DOSIFICACION
EFFET DOSE
INHIBICION
INHIBITION
MECANISME DE DEFENSE
MECANISMOS DE DEFENSA
NEOPLASMAS
NEOPLASME
NEOPLASMS
ORAL ADMINISTRATION
SARCOMA
Sarcoma 180
SARCOME
TREHALOSA
TREHALOSE
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Summary:An antitumor activity on oral administration of trehalose was investigated by using ICR mice implanted Sarcoma 180. After implanting of Sarcoma 180, five kinds of saline solutions containing trehalose (10 to 250 mg/kg) were administrated to mice daily for 10 days. The antitumor effect of trehalose was evaluated by measuring tumor sizes for 3 weeks and tumor weights on week 3. Approximately 70% inhibition ratio was observed in the tested groups admistered a dose higher than dose of 25 mg/kg.
ISSN:1344-7882
1880-7291
DOI:10.5458/jag.52.367