Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells

Angiogenesis is essential for tumor growth and vascular endothelial cell growth factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation...

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Published in:BMB reports 2009-10, Vol.42 (10), p.685-690
Main Authors: Heo, K., National Cancer Center, Goyang, Republic of Korea, Park, K.A., Pohang University of Science and Technology, Pohang, Republic of Korea, Kim, Y.H., National Cancer Center, Goyang, Republic of Korea, Kim, S.H., Pohang University of Science and Technology, Pohang, Republic of Korea, Oh, Y.S., Pohang University of Science and Technology, Pohang, Republic of Korea, Kim, I.H., National Cancer Center, Goyang, Republic of Korea, Ryu, S.H., Pohang University of Science and Technology, Pohang, Republic of Korea, Suh, P.G., Pohang University of Science and Technology, Pohang, Republic of Korea
Format: Article
Language:English
Subjects:
Angiogenesis
CELLS
CELLULE
CELULAS
Endothelial cell
Promoter
Sphingosine 1-phosphate
Vascular endothelial cell growth factor
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Summary:Angiogenesis is essential for tumor growth and vascular endothelial cell growth factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration. in this study, the authors found that S1P increases the level of VEGF mRNA in human umbilical vein endothelial cells (HUVECs) and immortalized HUVECs (iHUVECs). Additionally, S1P was found to increase VEGF promoter activity in MS-1 mouse pancreatic islet endothelial cells. Furthermore, a pharmacological inhibitory study revealed that G∧αi/o-mediated phospholipase C, Akt, Erk, and p38 MAPK signaling are involved in this S1P-induced expression of VEGF. A component of AN transcription factor is important for S1P-induced VEGF expression. Taken together, these findings suggest that S1P enhances endothelial cell proliferation and migration by upregulating the expression of VEGF mRNA.
ISSN:1976-6696
DOI:10.5483/bmbrep.2009.42.10.685