Pharmacokinetics of high-dose isoniazid in children affected by multidrug-resistant TB

BACKGROUND: High-dose isoniazid (INHH) (15-20 mg/kg/day) could be administered to overcome low-level INH resistance, but pharmacokinetic data are sparse.METHODS: This observational study included South African children (

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Bibliographic Details
Published in:The international journal of tuberculosis and lung disease 2021-11, Vol.25 (11), p.896-902
Main Authors: Winckler, J. L., Schaaf, H. S., Draper, H. R., McIlleron, H., Norman, J., van der Laan, L. E., Wiesner, L., Donald, P. R., Hesseling, A. C., Garcia-Prats, A. J.
Format: Article
Language:English
Subjects:
Children
Drugs
Exposure
HIV
Human immunodeficiency virus
Isoniazid
Multidrug resistance
Multidrug resistant organisms
Paediatric
Pharmacokinetics
Pharmacology
Prevention
Regression analysis
Regression models
Therapy
Tuberculosis
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Description
Summary:BACKGROUND: High-dose isoniazid (INHH) (15-20 mg/kg/day) could be administered to overcome low-level INH resistance, but pharmacokinetic data are sparse.METHODS: This observational study included South African children (
ISSN:1027-3719
1815-7920
DOI:10.5588/ijtld.20.0870