Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of...

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Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2014-03, Vol.30, p.193-201
Main Authors: Mishra, Arun, Rathod, Jaynt, Namera, Dipti, Thakrar, Shailesh, Shah, Anamik
Format: Article
Language:English
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Summary:We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1 H NMR, 13 C NMR and elemental analysis. Moreover, all synthesized compounds were screened for In Vitro antimicrobial activity against the gram positive ( Staphylococcus aureus , Bacilluas subtilis ) and gram negative ( Escherichia coli , P. aeruginosa , K. pneunonae , Enterobacter ) bacterial strain. In which some the compounds show potential inhibition against the test organisms.
ISSN:2299-3843
2299-3843
DOI:10.56431/p-jf8m8p