Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4...

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Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2015-04, Vol.49, p.149-154
Main Authors: Bhuva, V.V., Bhadani, V.N., Purohit, H.D., Purohit, Dipak M.
Format: Article
Language:English
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Summary:3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1 H-NMR, Mass spectral data, elemental analysis and thin layer chromatography. Keyw ords : Cyanopyrans; antibacterial activity; antifungal activity
ISSN:2299-3843
2299-3843
DOI:10.56431/p-nhm2l9