Synthesis of Zwitterionic Phospholipid-Connected Silane Coupling Agents and Their Hybridization with Graphene Oxide

The hybridization of lipids with graphene is expected to produce a promising, novel biomaterial. However, there are limited examples of the covalent introduction of lipid molecules, especially the immobilization of lipid molecules, onto graphene on a substrate. Therefore, we investigated the hybridi...

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Bibliographic Details
Published in:Journal of Oleo Science 2024, Vol.73(6), pp.857-863
Main Authors: Arita, Kanato, Yarimizu, Seina, Moriguchi, Maiko, Inoue, Tsuyoshi, Asahara, Haruyasu
Format: Article
Language:English
Subjects:
electron microscopy
graphene
oxidative modification
phospholipids
proteins
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Summary:The hybridization of lipids with graphene is expected to produce a promising, novel biomaterial. However, there are limited examples of the covalent introduction of lipid molecules, especially the immobilization of lipid molecules, onto graphene on a substrate. Therefore, we investigated the hybridization of a silane coupling agent having phospholipid moieties with graphene oxide on substrates prepared by photo-oxidation using chlorine dioxide. Three silane coupling agents with different carbon chain lengths (C4, C6, C8) were synthesized and phospholipid molecules were introduced onto graphene on a substrate. Phospholipid-immobilized graphene on a grid for TEM (transmission electron microscope) was used for EM analysis of proteins (glyceraldehyde 3-phosphate dehydrogenase and β-galactosidase), enabling the observation of sufficient particles compared to the conventional graphene grid.
ISSN:1345-8957
1347-3352
DOI:10.5650/jos.ess24044