Assessment of mean platelet volume in type 2 diabetics receiving insulin or oral antidiabetic agents

• Published in: Dicle tıp dergisi 2015-12, Vol.42 (4)
• Main Authors: Şahpaz, Fatih, Dumlupınar University Faculty of Medicine, Department of Internal Medicine, Kütahya, Turkey, Ulutaş, Kemal Türker, Kadirli State Hospital, Central Laboratory of Medical Biochemistry, Osmaniye, Turkey
• Format: Article
• Language: English
• ISSN: 1300-2945; 1308-9889; 1308-9889
• DOI: 10.5798/diclemedj.0921.2015.04.0598

Objective: Increased mean platelet volume (MPV) is a known risk factor for various acute vascular complications, which is commonly associated with patients with diabetes mellitus (DM). This study was aimed to investigate the association of MPV, Type 2 DM and to know the difference of MPV in patients on oral hypoglycemic drugs and insulin therapy.Methods: A total of 300 patients were selected and allocated to three subgroups with 100, as DM Group on insulin therapy, DM Group on oral hypoglycemic therapy and non-DM Group (Negative control Group). Investigations like fasting blood glucose, HbA1c and MPV were performed. The results of patient values were evaluated retrospectively.Results: Results of the study showed that patients with type 2 DM have increased in the MPV. Oral antidiabetic treatment in patients MPV, was found to be higher compared to patients treated with insulin. The mean MPV in Group 1 (on oral hypoglycemic treatment) was 10.07±0.7 fl, in Group 2 (on Insulin therapy) 9.01±0.6 fl and in the controls Group 8.15±0.8 fl.Conclusion: The outcome of study has shown that values of MPV are increased in patients with, Type 2 DM and are significantly higher in those patients on oral hypoglycemic therapy than patients on insulin therapy. MPV is a simple and cost-effective tool which can be explored for predicting the possibility of vascular events in patients suffering from diabetes mellitus. Early initiation of insulin treatment in confirmed cases of Type 2 diabetics not only helps in controlling blood glucose level but also helps in keeping MPV low and thereby preventing possibility of impending vascular events.Key words: Mean platelet volume, type 2 diabetes mellitus, insulin therapy, oral hypoglycemic drugs