THE ROLE OF INFLAMMATORY PARAMETERS AND SCORING SYSTEMS IN PREDICTING COMPLICATED ACUTE APPENDICITIS

• Published in: Meandros medical and dental journal 2024-09, Vol.25 (3), p.305-316
• Main Authors: Kaya, Mehmet Gökhan, Acar, Ethem
• Format: Article
• Language: English
• ISSN: 2149-9063; 2149-9063
• DOI: 10.69601/meandrosmdj.1528717

Aim: To assess the complications associated with acute appendicitis (AA) and to evaluate how specific routine patient parameters influence disease severity. Materials and Methods: A retrospective study was carried out on patients diagnosed with AA who presented to the emergency department (ED) between January 1, 2019, and December 31, 2020. Data collected included demographic details, blood test results, and specific scoring systems utilized in the ED. Results: Of the 223 patients studied, 63.7% were male with a mean age of 37.5 ± 16.8 years. Patients with complicated appendicitis (CA) showed significantly elevated hematological parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), systemic immune inflammation index (SII), white blood cell count (WBC), and neutrophil levels. Conversely, decreased lymphocyte/C-reactive protein ratio (LCRP) and lymphocyte levels were noted. Furthermore, CA cases exhibited significantly greater Appendicitis Inflammatory Response (AIR) and Alvarado scores. In the context of diagnosing CA, the AIR score had a sensitivity of 85.9% and a specificity of 47.9% with a cut-off value of ≥6 (95% CI 0.675-0.821, Area Under the Curve (AUC): 0.748; p