MEGALOMICIN, A NEW MACROLIDE ANTIBIOTIC COMPLEX PRODUCED BY MICROMONOSPORA

A new macrolide antibiotic complex has been isolated from fermentation broths of two strains of a news pecies of Micromonospora, M. megalomicea sp. n. The antibiotic complex has been differentiated from other known macrolides and methods for its production, isolation and separation of components hav...

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Bibliographic Details
Published in:Journal of antibiotics 1969/06/25, Vol.22(6), pp.253-258
Main Authors: WEINSTEIN, MARVIN J., WAGMAN, GERALD H., MARQUEZ, Joseph A., TESTA, RAYMOND T., ODEN, EDWIN, WAITZ, J. ALLAN
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - toxicity
Bacteria - drug effects
Chromatography, Thin Layer
Culture Media
Dogs
Erythromycin - pharmacology
Male
Mice
Micromonospora - analysis
Micromonospora - metabolism
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Summary:A new macrolide antibiotic complex has been isolated from fermentation broths of two strains of a news pecies of Micromonospora, M. megalomicea sp. n. The antibiotic complex has been differentiated from other known macrolides and methods for its production, isolation and separation of components have been devised. Like other macrolides, it is primarily active against gram-positive bacteria and is more active at an alkaline pH. Of the four known components, megalomicin A has been studied most extensively. It has activity equal to or slightly less than that of erythromycin both in vitro and in vivo. In dogs dosed orally, it is better tolerated and gives higher peak serum levels with a much greater duration than erythromycin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.22.253