STIGMATELLIN, A NEW ANTIBIOTIC FROM STIGMATELLA AURANTIACA (MYXOBACTERALES): I. PRODUCTION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

An antibiotic activity was extracted from the cell mass of the myxobacterium, Stiginatella aurantiaca strain Sg a15. The antibiotic was toxic for yeasts and filamentous fungi, but not for most bacteria. The compound had the molecular formula C30H42O7, appears to be a new antibiotic, and was named st...

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(5), pp.454-461
Main Authors: KUNZE, B., KEMMER, T., HÖFLE, G., REICHENBACH, H.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Fermentation
Fundamental and applied biological sciences. Psychology
General pharmacology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Microbial Sensitivity Tests
Myxococcales - metabolism
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Polyenes - biosynthesis
Polyenes - pharmacology
Production of active biomolecules
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Summary:An antibiotic activity was extracted from the cell mass of the myxobacterium, Stiginatella aurantiaca strain Sg a15. The antibiotic was toxic for yeasts and filamentous fungi, but not for most bacteria. The compound had the molecular formula C30H42O7, appears to be a new antibiotic, and was named stigmatellin. In addition to stigmatellin, the strain produced relatively large quantities of a second, structurally unrelated antibiotic, a mixture of three myxalamid homologues.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.454