BIPHENOMYCINS A AND B, NOVEL PEPTIDE ANTIBIOTICS: I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

Biphenomycin A, C23H28N4O8, and biphenomycin B, C23H28N4O7, were isolated from the cultured broth of Streptomyces griseorubiginosus No. 43708. The antibiotics are active in vitro and in vivo against bacteria, and are especially potent against Gram-positive bacteria. The acute toxicity of biphenomyci...

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Bibliographic Details
Published in:Journal of antibiotics 1985, Vol.38(11), pp.1453-1461
Main Authors: EZAKI, MASAMI, IWAMI, MORITA, YAMASHITA, MICHIO, HASHIMOTO, SEIJI, KOMORI, TADAAKI, UMEHARA, KAZUYOSHI, MINE, YASUHIRO, KOHSAKA, MASANOBU, AOKI, HATSUO, IMANAKA, HIROSHI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics
Bacteria - drug effects
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Dipeptides - pharmacology
Fermentation
Fundamental and applied biological sciences. Psychology
General pharmacology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Mice
Mice, Inbred ICR
Peptides
Peptides, Cyclic
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Production of active biomolecules
Streptomyces - classification
Streptomyces - metabolism
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Summary:Biphenomycin A, C23H28N4O8, and biphenomycin B, C23H28N4O7, were isolated from the cultured broth of Streptomyces griseorubiginosus No. 43708. The antibiotics are active in vitro and in vivo against bacteria, and are especially potent against Gram-positive bacteria. The acute toxicity of biphenomycin A is very low in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.1453