Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the re...

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Bibliographic Details
Published in:eLife 2024-10, Vol.13
Main Authors: Bomba-Warczak, Ewa K, Velez, Karen M, Zhou, Luhan T, Guillermier, Christelle, Edassery, Seby, Steinhauser, Matthew L, Savas, Jeffrey N, Duncan, Francesca E
Format: Article
Language:English
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Summary:The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type-specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.93172.3