Effects of Graded Doses of Ethanolic Extract of Pausinystalia Yohimbe Stem Bark on Biochemical and Hematological Indices In the Kidneys of Female Wistar Rats

• Published in: International journal of biochemistry research & review 2023-07, Vol.32 (4), p.23-36
• Main Authors: Okwakpam, F. N., Ken-Ezihuo, S. U., Ajie, P., Amadi, B. A.
• Format: Article
• Language: English
• ISSN: 2231-086X; 2231-086X
• DOI: 10.9734/ijbcrr/2023/v32i4810

Pausinystalia yohimbe is a medicinal plant widely used as an aphrodisiac agent in Nigeria and other parts of West Africa, but little is known about its effect on renal function after chronic use. This study was designed to investigate the effect of ethanolic extract of Pausinystalia yohimbe stem bark on renal function parameters such as serum creatinine, urea, electrolyte, oxidative stress markers, and hematological parameters in female Wistar rats. Ethanolic extract of Pausinystalia yohimbe stem bark was administered orally to 3 groups of 5 female rats for 21 days as follows: group1 which served as control received distilled water while groups 2 and 3 received 400mg/kg and 800mg/kg body weight of the extract respectively. Thereafter the rats were sacrificed, and blood and kidney tissues were collected for biochemical analysis.  The result showed that there were no significant changes in urea, creatinine, potassium, chloride, and bicarbonate levels while sodium level was significantly increased (p