Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart

Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocard...

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Bibliographic Details
Published in:Computers in biology and medicine 2013-11, Vol.43 (11), p.1698-1703
Main Authors: Marcé-Nogué, J, Fortuny, G, Ballester-Rodés, M, Carreras, F, Roure, F
Format: Article
Language:English
Subjects:
Action potential
Action Potentials - physiology
Activation
Aplicacions de la informàtica
Biologia computacional
Cardiac mechanics
Ciències de la salut
Computational biology
Computer Simulation
Electro-mechanical sequence
Fibers
Finite element analysis
Heart
Heart - anatomy & histology
Heart - physiology
Heart Ventricles - anatomy & histology
Helical myocardial ventricular band
Humans
Informàtica
Internal Medicine
Mathematical models
Mechanics
Medicina
Methods
Models, Cardiovascular
Myocardial Contraction - physiology
Myocardium
Other
Partial differential equations
Propagation
Pulmonary arteries
Studies
Ventricular Function - physiology
Àrees temàtiques de la UPC
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Description
Summary:Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocardial fibers. To further investigate the sequence of electromechanical propagation based on the helical architecture of the heart, a simplified computational model was designed. This model was then used to test four activation patterns, which were generated by propagating the action potential along the myocardial band from different activation sites.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2013.07.016