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Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart
Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocard...
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| Published in: | Computers in biology and medicine 2013-11, Vol.43 (11), p.1698-1703 |
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| cites | cdi_FETCH-LOGICAL-c582t-c14b8cee8265471c47ee923211bd4e06f90bf926d4cc5a0c98b2b06e002e14ac3 |
| container_end_page | 1703 |
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| container_title | Computers in biology and medicine |
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| creator | Marcé-Nogué, J Fortuny, G Ballester-Rodés, M Carreras, F Roure, F |
| description | Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocardial fibers. To further investigate the sequence of electromechanical propagation based on the helical architecture of the heart, a simplified computational model was designed. This model was then used to test four activation patterns, which were generated by propagating the action potential along the myocardial band from different activation sites. |
| doi_str_mv | 10.1016/j.compbiomed.2013.07.016 |
| format | article |
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However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocardial fibers. To further investigate the sequence of electromechanical propagation based on the helical architecture of the heart, a simplified computational model was designed. This model was then used to test four activation patterns, which were generated by propagating the action potential along the myocardial band from different activation sites.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2013.07.016</identifier><identifier>PMID: 24209915</identifier><identifier>CODEN: CBMDAW</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Action potential ; Action Potentials - physiology ; Activation ; Aplicacions de la informàtica ; Biologia computacional ; Cardiac mechanics ; Ciències de la salut ; Computational biology ; Computer Simulation ; Electro-mechanical sequence ; Fibers ; Finite element analysis ; Heart ; Heart - anatomy & histology ; Heart - physiology ; Heart Ventricles - anatomy & histology ; Helical myocardial ventricular band ; Humans ; Informàtica ; Internal Medicine ; Mathematical models ; Mechanics ; Medicina ; Methods ; Models, Cardiovascular ; Myocardial Contraction - physiology ; Myocardium ; Other ; Partial differential equations ; Propagation ; Pulmonary arteries ; Studies ; Ventricular Function - physiology ; Àrees temàtiques de la UPC</subject><ispartof>Computers in biology and medicine, 2013-11, Vol.43 (11), p.1698-1703</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2013 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2013</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-c14b8cee8265471c47ee923211bd4e06f90bf926d4cc5a0c98b2b06e002e14ac3</citedby><cites>FETCH-LOGICAL-c582t-c14b8cee8265471c47ee923211bd4e06f90bf926d4cc5a0c98b2b06e002e14ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24209915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcé-Nogué, J</creatorcontrib><creatorcontrib>Fortuny, G</creatorcontrib><creatorcontrib>Ballester-Rodés, M</creatorcontrib><creatorcontrib>Carreras, F</creatorcontrib><creatorcontrib>Roure, F</creatorcontrib><title>Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart</title><title>Computers in biology and medicine</title><addtitle>Comput Biol Med</addtitle><description>Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocardial fibers. To further investigate the sequence of electromechanical propagation based on the helical architecture of the heart, a simplified computational model was designed. This model was then used to test four activation patterns, which were generated by propagating the action potential along the myocardial band from different activation sites.</description><subject>Action potential</subject><subject>Action Potentials - physiology</subject><subject>Activation</subject><subject>Aplicacions de la informàtica</subject><subject>Biologia computacional</subject><subject>Cardiac mechanics</subject><subject>Ciències de la salut</subject><subject>Computational biology</subject><subject>Computer Simulation</subject><subject>Electro-mechanical sequence</subject><subject>Fibers</subject><subject>Finite element analysis</subject><subject>Heart</subject><subject>Heart - anatomy & histology</subject><subject>Heart - physiology</subject><subject>Heart Ventricles - anatomy & histology</subject><subject>Helical myocardial ventricular band</subject><subject>Humans</subject><subject>Informàtica</subject><subject>Internal Medicine</subject><subject>Mathematical models</subject><subject>Mechanics</subject><subject>Medicina</subject><subject>Methods</subject><subject>Models, Cardiovascular</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardium</subject><subject>Other</subject><subject>Partial differential equations</subject><subject>Propagation</subject><subject>Pulmonary arteries</subject><subject>Studies</subject><subject>Ventricular Function - physiology</subject><subject>Àrees temàtiques de la UPC</subject><issn>0010-4825</issn><issn>1879-0534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkk2P0zAQhiMEYrsLfwFF4sIlYcZxvi5IUAGLtBIHQOJmOZNp65LExXZW6r_HoV1V2tMeLNt6n5mx550kSRFyBKze73Oy46EzduQ-F4BFDnUehWfJCpu6zaAs5PNkBYCQyUaUV8m193sAkFDAy-RKSAFti-Uq2a5jojnoYOykh3S0PQ9m2qZ2k_LAFFwsQTs9GYrqwdmD3v5nUzOlYcfpLuKLdM9TcIbmQbtUTzrY8bjkOCHahVfJi40ePL8-7zfJry-ff65vs7vvX7-tP95lVDYiZISya4i5EVUpayRZM7eiEIhdLxmqTQvdphVVL4lKDdQ2neigYgDBKDUVNwme8pKfSTkmdqSDstpcLssSUAslsJUFxJh3p5j4v78z-6BG44mHQU9sZ69QVrLEUkh8AloC1k0t6oi-fYTu7exikxdKtlhUdVNGqjm_11nvHW_UwZlRu6NCUIvXaq8uXqvFawW1ikIMfXMuMHeL9hD4YG4EPp0Ajg2_N-yUJ8MTcW9iL4LqrXlKlQ-PklAckMXzP3xkf_mT8kKB-rHM3DJyWMRTC7-Lf3cU1LM</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Marcé-Nogué, J</creator><creator>Fortuny, G</creator><creator>Ballester-Rodés, M</creator><creator>Carreras, F</creator><creator>Roure, F</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>XX2</scope></search><sort><creationdate>20131101</creationdate><title>Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart</title><author>Marcé-Nogué, J ; Fortuny, G ; Ballester-Rodés, M ; Carreras, F ; Roure, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-c14b8cee8265471c47ee923211bd4e06f90bf926d4cc5a0c98b2b06e002e14ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Action potential</topic><topic>Action Potentials - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Recercat</collection><jtitle>Computers in biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcé-Nogué, J</au><au>Fortuny, G</au><au>Ballester-Rodés, M</au><au>Carreras, F</au><au>Roure, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart</atitle><jtitle>Computers in biology and medicine</jtitle><addtitle>Comput Biol Med</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>43</volume><issue>11</issue><spage>1698</spage><epage>1703</epage><pages>1698-1703</pages><issn>0010-4825</issn><eissn>1879-0534</eissn><coden>CBMDAW</coden><abstract>Abstract The classical interpretation of myocardial activation assumes that the myocardium is homogeneous and that the electrical propagation is radial. However, anatomical studies have described a layered anatomical structure resulting from a continuous anatomical helical disposition of the myocardial fibers. To further investigate the sequence of electromechanical propagation based on the helical architecture of the heart, a simplified computational model was designed. This model was then used to test four activation patterns, which were generated by propagating the action potential along the myocardial band from different activation sites.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>24209915</pmid><doi>10.1016/j.compbiomed.2013.07.016</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Computers in biology and medicine, 2013-11, Vol.43 (11), p.1698-1703 |
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| source | ScienceDirect Freedom Collection |
| subjects | Action potential Action Potentials - physiology Activation Aplicacions de la informàtica Biologia computacional Cardiac mechanics Ciències de la salut Computational biology Computer Simulation Electro-mechanical sequence Fibers Finite element analysis Heart Heart - anatomy & histology Heart - physiology Heart Ventricles - anatomy & histology Helical myocardial ventricular band Humans Informàtica Internal Medicine Mathematical models Mechanics Medicina Methods Models, Cardiovascular Myocardial Contraction - physiology Myocardium Other Partial differential equations Propagation Pulmonary arteries Studies Ventricular Function - physiology Àrees temàtiques de la UPC |
| title | Computational modeling of electromechanical propagation in the helical ventricular anatomy of the heart |
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