Withdrawing inactive NRTIs in HIV-1 subjects with suppressed viraemia: a randomized trial

Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. This was a multicentre, randomized, prospective study. Subjects with at least o...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2016-05, Vol.71 (5), p.1346-1351
Main Authors: Llibre, Josep M, Alvarez, Hortensia, Antela, Antonio, Toro, Jessica, Payeras, Antoni, Pérez-Elías, M Jesús, Imaz, Arkaitz, Masià, Mar, Pérez-Alvarez, Núria, Burgos, Joaquin, Clotet, Bonaventura
Format: Article
Language:English
Subjects:
90 Operations research, mathematical programming
Adult
Aged
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Classificació AMS
Drug resistance
Drug-Related Side Effects and Adverse Reactions
Female
HIV
HIV Infections - drug therapy
HIV-1 - isolation & purification
Human immunodeficiency virus
Humans
Investigació operativa
Male
Matemàtiques i estadística
Medical treatment
Middle Aged
Mutation
Prospective Studies
Ribonucleic acid
RNA
Salvage Therapy - adverse effects
Salvage Therapy - methods
Treatment Outcome
Viral Load
Withholding Treatment
Àrees temàtiques de la UPC
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Description
Summary:Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. This was a multicentre, randomized, prospective study. Subjects with at least one prior VF, HIV-1 RNA
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkv461