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Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases
There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independ...
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| Published in: | International journal of cancer 2017-08 |
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| creator | Rakislova, Natalia Clavero, Omar Alemany i Vilches, Laia Saco, Adela Quirós, Beatriz Lloveras Rubio, Belén Alejo, Maria Pawlita, Michael Quint, Wim Pino, Marta del Sanjosé Llongueras, Silvia de Ordi i Majà, Jaume |
| description | There are at least two different etio-pathogenic pathways for
the development of vulvar squamous cell carcinoma (VSCC): one
associated with infection by human papillomavirus (HPV) and
another independent of HPV. We aimed to describe the
histological characteristics of HPV-associated and
HPV-independent tumors and to determine the best strategy to
identify HPV in VSCC. A single paraffin block was available for
review from a series of 1594 VSCCs. In all cases HPV DNA
detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and
p16 immunohistochemistry (IHC). A tumor was considered as
unquestionably HPV-associated if both HPV DNA and p16 IHC were
positive. A tumor was considered indisputably HPV-independent if
both HPV DNA and p16 IHC were negative. Two groups of tumors
were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV
DNA-/p16+. WHO typing and a thorough histological evaluation
were conducted in all cases. 441 tumors were HPV DNA+ with 367
cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors
were more frequently basaloid or warty (49.8%), but 36.5% were
of the keratinizing type. 1153 tumors were HPV DNA-, with 1060
cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors
were mostly keratinizing (81.2%) but were occasionally basaloid
or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were
similar to those of the HPV-associated VSCC, and HPV DNA+/p16-
(n=74) cases had a more diverse profile, although they were more
similar to HPV-independent tumors. Several histological
characteristics were more frequently associated with HPV-related
VSCC (koilocytotic-like change, necrosis, moderate to marked
pleomorphism, invasive front in nests; p |
| format | article |
| fullrecord | <record><control><sourceid>csuc</sourceid><recordid>TN_cdi_csuc_recercat_oai_recercat_cat_2072_302230</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_recercat_cat_2072_302230</sourcerecordid><originalsourceid>FETCH-csuc_recercat_oai_recercat_cat_2072_3022303</originalsourceid><addsrcrecordid>eNqdTMtqAkEQnEMCauI_9A8s9Mz6QG8ikT16CLkuTW8bR8adZHpGEPx41xDIPYeqooqqejJjRIfV0taLkZmonhCtneNsbG6N1xxD_PRMAfhIiThLGkLPCvEAzf6jItXInrJ0QH0Hle87-ZKB-gz6XegciwJLGA4ose_jmX62-ShwKeFCa9iA5tJdH6mdr2ZDUUVfzfOBgsr0V1-M3b29b5uKtXCbhCUx5TaS_zMPOFy6tkbnaqz_s7kDWpFYHg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases</title><source>Wiley</source><creator>Rakislova, Natalia ; Clavero, Omar ; Alemany i Vilches, Laia ; Saco, Adela ; Quirós, Beatriz ; Lloveras Rubio, Belén ; Alejo, Maria ; Pawlita, Michael ; Quint, Wim ; Pino, Marta del ; Sanjosé Llongueras, Silvia de ; Ordi i Majà, Jaume</creator><creatorcontrib>Rakislova, Natalia ; Clavero, Omar ; Alemany i Vilches, Laia ; Saco, Adela ; Quirós, Beatriz ; Lloveras Rubio, Belén ; Alejo, Maria ; Pawlita, Michael ; Quint, Wim ; Pino, Marta del ; Sanjosé Llongueras, Silvia de ; Ordi i Majà, Jaume</creatorcontrib><description>There are at least two different etio-pathogenic pathways for
the development of vulvar squamous cell carcinoma (VSCC): one
associated with infection by human papillomavirus (HPV) and
another independent of HPV. We aimed to describe the
histological characteristics of HPV-associated and
HPV-independent tumors and to determine the best strategy to
identify HPV in VSCC. A single paraffin block was available for
review from a series of 1594 VSCCs. In all cases HPV DNA
detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and
p16 immunohistochemistry (IHC). A tumor was considered as
unquestionably HPV-associated if both HPV DNA and p16 IHC were
positive. A tumor was considered indisputably HPV-independent if
both HPV DNA and p16 IHC were negative. Two groups of tumors
were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV
DNA-/p16+. WHO typing and a thorough histological evaluation
were conducted in all cases. 441 tumors were HPV DNA+ with 367
cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors
were more frequently basaloid or warty (49.8%), but 36.5% were
of the keratinizing type. 1153 tumors were HPV DNA-, with 1060
cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors
were mostly keratinizing (81.2%) but were occasionally basaloid
or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were
similar to those of the HPV-associated VSCC, and HPV DNA+/p16-
(n=74) cases had a more diverse profile, although they were more
similar to HPV-independent tumors. Several histological
characteristics were more frequently associated with HPV-related
VSCC (koilocytotic-like change, necrosis, moderate to marked
pleomorphism, invasive front in nests; p<0.001), however,
none of these characteristics allowed differentiation between
HPV-associated and -independent VSCC. In conclusion,
histological criteria do not allow differentiation between
HPV-associated and -independent VSCC. p16 alone is a clinically
easy strategy to determine HPV status in VSCC. This article is
protected by copyright. All rights reserved.</description><identifier>ISSN: 0020-7136</identifier><language>eng</language><publisher>Wiley</publisher><subject>Malalties de la vulva ; Papillomaviruses ; Papil·lomavirus ; Vulva diseases</subject><ispartof>International journal of cancer, 2017-08</ispartof><rights>(c) Wiley, 2017 info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids></links><search><creatorcontrib>Rakislova, Natalia</creatorcontrib><creatorcontrib>Clavero, Omar</creatorcontrib><creatorcontrib>Alemany i Vilches, Laia</creatorcontrib><creatorcontrib>Saco, Adela</creatorcontrib><creatorcontrib>Quirós, Beatriz</creatorcontrib><creatorcontrib>Lloveras Rubio, Belén</creatorcontrib><creatorcontrib>Alejo, Maria</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><creatorcontrib>Quint, Wim</creatorcontrib><creatorcontrib>Pino, Marta del</creatorcontrib><creatorcontrib>Sanjosé Llongueras, Silvia de</creatorcontrib><creatorcontrib>Ordi i Majà, Jaume</creatorcontrib><title>Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases</title><title>International journal of cancer</title><description>There are at least two different etio-pathogenic pathways for
the development of vulvar squamous cell carcinoma (VSCC): one
associated with infection by human papillomavirus (HPV) and
another independent of HPV. We aimed to describe the
histological characteristics of HPV-associated and
HPV-independent tumors and to determine the best strategy to
identify HPV in VSCC. A single paraffin block was available for
review from a series of 1594 VSCCs. In all cases HPV DNA
detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and
p16 immunohistochemistry (IHC). A tumor was considered as
unquestionably HPV-associated if both HPV DNA and p16 IHC were
positive. A tumor was considered indisputably HPV-independent if
both HPV DNA and p16 IHC were negative. Two groups of tumors
were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV
DNA-/p16+. WHO typing and a thorough histological evaluation
were conducted in all cases. 441 tumors were HPV DNA+ with 367
cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors
were more frequently basaloid or warty (49.8%), but 36.5% were
of the keratinizing type. 1153 tumors were HPV DNA-, with 1060
cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors
were mostly keratinizing (81.2%) but were occasionally basaloid
or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were
similar to those of the HPV-associated VSCC, and HPV DNA+/p16-
(n=74) cases had a more diverse profile, although they were more
similar to HPV-independent tumors. Several histological
characteristics were more frequently associated with HPV-related
VSCC (koilocytotic-like change, necrosis, moderate to marked
pleomorphism, invasive front in nests; p<0.001), however,
none of these characteristics allowed differentiation between
HPV-associated and -independent VSCC. In conclusion,
histological criteria do not allow differentiation between
HPV-associated and -independent VSCC. p16 alone is a clinically
easy strategy to determine HPV status in VSCC. This article is
protected by copyright. All rights reserved.</description><subject>Malalties de la vulva</subject><subject>Papillomaviruses</subject><subject>Papil·lomavirus</subject><subject>Vulva diseases</subject><issn>0020-7136</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqdTMtqAkEQnEMCauI_9A8s9Mz6QG8ikT16CLkuTW8bR8adZHpGEPx41xDIPYeqooqqejJjRIfV0taLkZmonhCtneNsbG6N1xxD_PRMAfhIiThLGkLPCvEAzf6jItXInrJ0QH0Hle87-ZKB-gz6XegciwJLGA4ose_jmX62-ShwKeFCa9iA5tJdH6mdr2ZDUUVfzfOBgsr0V1-M3b29b5uKtXCbhCUx5TaS_zMPOFy6tkbnaqz_s7kDWpFYHg</recordid><startdate>20170831</startdate><enddate>20170831</enddate><creator>Rakislova, Natalia</creator><creator>Clavero, Omar</creator><creator>Alemany i Vilches, Laia</creator><creator>Saco, Adela</creator><creator>Quirós, Beatriz</creator><creator>Lloveras Rubio, Belén</creator><creator>Alejo, Maria</creator><creator>Pawlita, Michael</creator><creator>Quint, Wim</creator><creator>Pino, Marta del</creator><creator>Sanjosé Llongueras, Silvia de</creator><creator>Ordi i Majà, Jaume</creator><general>Wiley</general><scope>XX2</scope></search><sort><creationdate>20170831</creationdate><title>Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases</title><author>Rakislova, Natalia ; Clavero, Omar ; Alemany i Vilches, Laia ; Saco, Adela ; Quirós, Beatriz ; Lloveras Rubio, Belén ; Alejo, Maria ; Pawlita, Michael ; Quint, Wim ; Pino, Marta del ; Sanjosé Llongueras, Silvia de ; Ordi i Majà, Jaume</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-csuc_recercat_oai_recercat_cat_2072_3022303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Malalties de la vulva</topic><topic>Papillomaviruses</topic><topic>Papil·lomavirus</topic><topic>Vulva diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rakislova, Natalia</creatorcontrib><creatorcontrib>Clavero, Omar</creatorcontrib><creatorcontrib>Alemany i Vilches, Laia</creatorcontrib><creatorcontrib>Saco, Adela</creatorcontrib><creatorcontrib>Quirós, Beatriz</creatorcontrib><creatorcontrib>Lloveras Rubio, Belén</creatorcontrib><creatorcontrib>Alejo, Maria</creatorcontrib><creatorcontrib>Pawlita, Michael</creatorcontrib><creatorcontrib>Quint, Wim</creatorcontrib><creatorcontrib>Pino, Marta del</creatorcontrib><creatorcontrib>Sanjosé Llongueras, Silvia de</creatorcontrib><creatorcontrib>Ordi i Majà, Jaume</creatorcontrib><collection>Recercat</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rakislova, Natalia</au><au>Clavero, Omar</au><au>Alemany i Vilches, Laia</au><au>Saco, Adela</au><au>Quirós, Beatriz</au><au>Lloveras Rubio, Belén</au><au>Alejo, Maria</au><au>Pawlita, Michael</au><au>Quint, Wim</au><au>Pino, Marta del</au><au>Sanjosé Llongueras, Silvia de</au><au>Ordi i Majà, Jaume</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases</atitle><jtitle>International journal of cancer</jtitle><date>2017-08-31</date><risdate>2017</risdate><issn>0020-7136</issn><abstract>There are at least two different etio-pathogenic pathways for
the development of vulvar squamous cell carcinoma (VSCC): one
associated with infection by human papillomavirus (HPV) and
another independent of HPV. We aimed to describe the
histological characteristics of HPV-associated and
HPV-independent tumors and to determine the best strategy to
identify HPV in VSCC. A single paraffin block was available for
review from a series of 1594 VSCCs. In all cases HPV DNA
detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and
p16 immunohistochemistry (IHC). A tumor was considered as
unquestionably HPV-associated if both HPV DNA and p16 IHC were
positive. A tumor was considered indisputably HPV-independent if
both HPV DNA and p16 IHC were negative. Two groups of tumors
were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV
DNA-/p16+. WHO typing and a thorough histological evaluation
were conducted in all cases. 441 tumors were HPV DNA+ with 367
cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors
were more frequently basaloid or warty (49.8%), but 36.5% were
of the keratinizing type. 1153 tumors were HPV DNA-, with 1060
cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors
were mostly keratinizing (81.2%) but were occasionally basaloid
or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were
similar to those of the HPV-associated VSCC, and HPV DNA+/p16-
(n=74) cases had a more diverse profile, although they were more
similar to HPV-independent tumors. Several histological
characteristics were more frequently associated with HPV-related
VSCC (koilocytotic-like change, necrosis, moderate to marked
pleomorphism, invasive front in nests; p<0.001), however,
none of these characteristics allowed differentiation between
HPV-associated and -independent VSCC. In conclusion,
histological criteria do not allow differentiation between
HPV-associated and -independent VSCC. p16 alone is a clinically
easy strategy to determine HPV status in VSCC. This article is
protected by copyright. All rights reserved.</abstract><pub>Wiley</pub><tpages>37</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley |
| subjects | Malalties de la vulva Papillomaviruses Papil·lomavirus Vulva diseases |
| title | Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases |
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