A randomized controlled trial: branched‐chain amino acid levels and glucose metabolism in patients with obesity and sleep apnea

Summary There is evidence that changes in branched‐chain amino acid (BCAA) levels may correlate with the efficacy of therapeutic interventions for affecting improvement in metabolic control. The objective of this study was to evaluate whether serum concentrations of BCAAs (leucine, isoleucine, valin...

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Bibliographic Details
Published in:Journal of sleep research 2017-12, Vol.26 (6), p.773-781
Main Authors: Barceló, Antonia, Morell‐Garcia, Daniel, Salord, Neus, Esquinas, Cristina, Pérez, Gerardo, Pérez, Antonio, Monasterio, Carmen, Gasa, Merce, Fortuna, Ana Maria, Montserrat, Josep Maria, Mayos, Mercedes
Format: Article
Language:English
Subjects:
Adult
Amino acids
Amino Acids, Branched-Chain - blood
Amino Acids, Branched-Chain - metabolism
Aminoàcids
Artificial respiration
Blood Glucose - metabolism
branched‐chain
Continuous Positive Airway Pressure
Fasting - blood
Female
Glucosa
Glucose
Glucose Intolerance
glucose tolerance
Glycated Hemoglobin A - analysis
Humans
Insulin Resistance
Isoleucine - blood
Leucine - blood
Male
Metabolic regulation
Middle Aged
Morbid obesity
Obesitat mòrbida
Obesity, Morbid - blood
Obesity, Morbid - complications
Obesity, Morbid - metabolism
obstructive sleep apnea
Prospective Studies
Regulació del metabolisme
Respiració artificial
Sleep apnea syndromes
Sleep Apnea, Obstructive - blood
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - metabolism
Sleep Apnea, Obstructive - therapy
Síndromes d'apnea del son
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Summary:Summary There is evidence that changes in branched‐chain amino acid (BCAA) levels may correlate with the efficacy of therapeutic interventions for affecting improvement in metabolic control. The objective of this study was to evaluate whether serum concentrations of BCAAs (leucine, isoleucine, valine) could mediate in insulin sensitivity and glucose tolerance after continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). A prospective randomized controlled trial of OSA patients with morbid obesity was conducted. Eighty patients were randomized into two groups: 38 received conservative treatment and 42 received CPAP treatment for 12 weeks. Plasma levels of BCAA, glucose tolerance and insulin resistance were evaluated at baseline and after treatment. After treatment, significant decreases of leucine levels were observed in both groups when compared with baseline levels (P 
ISSN:0962-1105
1365-2869
DOI:10.1111/jsr.12551