MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis

BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness...

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Published in:Cancer genomics & proteomics 2017
Main Authors: Fernández Rodríguez, M. Concepción, Bellosillo Paricio, Beatriz, Ferraro Rosset, Mariana Paola, Seoane, Agustín, Sanchez Gonzalez, Blanca, Pairet García, Silvia, Pons, A, Barranco Sanz, Luis Carlos, Vela Ortíz, María del Carmen, Gimeno Vázquez, Eva, Colomo Saperas, Luis Alberto, Besses Raebel, Carles, Navarro, Alfons, Salar Silvestre, Antonio
Format: Article
Language:English
Subjects:
Chronic gastritis
Estómac
Gastric MALT lymphoma
Inflamació
Limfomes
MicroRNAs
miR-155
miR-203
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Summary:BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness in gastric MALT lymphoma has not been extensively investigated. MATERIALS AND METHODS: We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes. Then, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis. RESULTS: Gastric MALT lymphoma is characterized by a specific miRNA expression profile. Among the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis. CONCLUSION: miR-142-3p, miR-155 and miR-203 expression levels might be helpful biomarkers for the differential diagnosis between gastric MALT lymphomas and chronic gastritis.
ISSN:1109-6535