Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma

The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailabilit...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2015-08, Vol.63 (31), p.6946-6953
Main Authors: Rodríguez-Morató, Jose, Farré, Magí, Pérez-Mañá, Clara, Papaseit, Esther, Martínez-Riera, Roser, de la Torre, Rafael, Pizarro, Nieves
Format: Article
Language:English
Subjects:
Adult
bioactive properties
bioavailability
Biological Availability
Chromatography, Liquid
daidzein
Dietary Supplements - analysis
Farmacocinètica
Female
genistein
Genistein - blood
Genistein - pharmacokinetics
Glycine max - metabolism
Humans
Isoflavones - blood
Isoflavones - pharmacokinetics
liquid chromatography
Male
pharmacokinetics
Plant Extracts - blood
Plant Extracts - pharmacokinetics
soja
Tandem Mass Spectrometry
volunteers
Young Adult
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Summary:The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailability and pharmacokinetics. This study describes the development and validation of an analytical method to detect and quantify daidzein, genistein, and equol in human plasma using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was applied in a crossover, randomized, bioavailability study. Twelve healthy volunteers were administered the same total isoflavones dose from two isoflavone supplement preparations (Super-Absorbable Soy Isoflavones (Life Extension, USA) and Fitoladius (Merck, Spain)). The pharmacokinetic parameters (AUC0–24/dose and C max/dose) of the isoflavones from the two preparations differed significantly. Such differences in bioavailability and kinetics may have relevant effects on the health benefits derived from their intake.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.5b02891