Transgenerational transmission of small for gestational age

Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational ag...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2018-09
Main Authors: Sepúlveda Martínez, Álvaro, Rodríguez López, Mérida, Paz Y Miño, Fernanda, Casu, Giulia, Crovetto, Francesca, Gratacós Solsona, Eduard, Crispi Brillas, Fàtima
Format: Article
Language:English
Subjects:
Creixement fetal
Fetal growth
Medicina prenatal
Prenatal medicine
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Summary:Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p
ISSN:0960-7692