Transgenerational transmission of small for gestational age

Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational ag...

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Published in:Ultrasound in obstetrics & gynecology 2018-09
Main Authors: Sepúlveda Martínez, Álvaro, Rodríguez López, Mérida, Paz Y Miño, Fernanda, Casu, Giulia, Crovetto, Francesca, Gratacós Solsona, Eduard, Crispi Brillas, Fàtima
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Language:English
Subjects:
Creixement fetal
Fetal growth
Medicina prenatal
Prenatal medicine
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container_title Ultrasound in obstetrics & gynecology
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creator Sepúlveda Martínez, Álvaro
Rodríguez López, Mérida
Paz Y Miño, Fernanda
Casu, Giulia
Crovetto, Francesca
Gratacós Solsona, Eduard
Crispi Brillas, Fàtima
description Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p
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Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight &lt; 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p&lt;0.001) and higher prevalence of SGA (40.3% vs. 16.3%; p=0.001) and placental mediated disease (43.1% vs. 17.5%; p=0.001). After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. 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After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. 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subjects Creixement fetal
Fetal growth
Medicina prenatal
Prenatal medicine
title Transgenerational transmission of small for gestational age
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