Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae

Streptococcus pneumoniae is the leading cause of vaccine-preventable deaths globally. The objective of this study was to determine the distribution and clonal type variability of three potential vaccine antigens: Pneumococcal serine-rich repeat protein (PsrP), Pilus-1, and Pneumococcal choline bindi...

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Published in:PloS one 2012-07
Main Authors: Selva Jové, Laura, Ciruela, Pilar, Blanchette, Krystle, Amo Moran, Eva del, Pallarés Giner, Roman, Orihuela, Carlos J, Muñoz-Almagro, Carmen
Format: Article
Language:English
Subjects:
Drug resistance
Infeccions per pneumococs
Pediatria
Pediatrics
Pneumococcal Infections
Pneumococcal vaccine
Pneumococs
Resistència als medicaments
Streptococcus pneumonia
Vaccination of children
Vaccines
Vacuna antipneumocòccica
Vacunació dels infants
Vacunes
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Summary:Streptococcus pneumoniae is the leading cause of vaccine-preventable deaths globally. The objective of this study was to determine the distribution and clonal type variability of three potential vaccine antigens: Pneumococcal serine-rich repeat protein (PsrP), Pilus-1, and Pneumococcal choline binding protein A (PcpA) among pneumococcal isolates from children with invasive pneumococcal disease and healthy nasopharyngeal carriers. We studied by Real-Time PCR a total of 458 invasive pneumococcal isolates and 89 nasopharyngeal pneumococcal isolates among children (total = 547 strains) collected in Barcelona, Spain, from January 2004 to July 2010. pcpA, psrP and pilus-1 were detected in 92.8%, 51.7% and 14.4% of invasive isolates and in 92.1%, 48.3% and 18% of carrier isolates, respectively. Within individual serotypes the prevalence of psrP and pilus-1 was highly dependent on the clonal type. pcpA was highly prevalent in all strains with the exception of those belonging to serotype 3 (33.3% in serotype 3 isolates vs. 95.1% in other serotypes; P
ISSN:1932-6203
1932-6203