Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

• Published in: World journal of clinical cases 2019-01
• Main Authors: Garrido-Marín, Marta, Argacha, Pedro Maria, Fernández, Luís, Molfino, Florencia, Martínez Soler, Fina, Tortosa i Moreno, Avelina, Giménez Bonafé, Pepita
• Format: Article
• Language: English
• Subjects: Breast cancer; Càncer de mama; Embaràs; Endometriosi; Endometriosis; Fecundació in vitro humana; Fecunditat; Fertility; Human in vitro fertilization; Pregnancy; Ressenyes sistemàtiques (Investigació mèdica); Systematic reviews (Medical research)
• ISSN: 2307-8960; 2307-8960

A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother. Several factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2], which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits. In contrast, the factors against success were: breast cancer; adjuvant breast cancer therapy gonadotoxicity; the age of the patient (> 40-year-old); endometriosis; ovarian cyst; hydrosalpinx; submucosal fibroids and the respective associated surgery done for the above-mentioned pathology (all resolved prior to the embryo transfer); and a low quantity of ovules (low ovarian reserve) after ovarian stimulation. This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies, who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding.