A randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement

n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a sta...

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Bibliographic Details
Published in:British journal of nutrition 2010-09
Main Authors: Badia Tahull, Maria Bella, Llop Talaverón, Josep Manuel, Leiva Badosa, Elisabet, Biondo, Sebastián, Farrán Teixidor, Leandre, Ramon Torrell, Josep M. (Josep Maria), Jódar Masanés, Ramón José
Format: Article
Language:English
Subjects:
Agents antiinfecciosos
Alimentació parenteral
Anti-infective agents
Cirurgia
Cura postoperatòria
Emulsions
Fish oils
Gastrointestinal system diseases
Malalties del tracte gastrointestinal
Olis de peix
Parenteral feeding
Postoperative care
Prevention programs
Programes de prevenció
Surgery
Therapeutic use
Ús terapèutic
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Summary:n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16.6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P < 0.05). Twenty-seven patients were evaluated, with thirteen patients receiving FO. In this group, a significantly lower incidence of infections was found (23.1 v. 78.6 %, P = 0.007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated.
ISSN:0007-1145