Combating virulence of Gramnegative bacilli by OmpA inhibition

Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us...

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Bibliographic Details
Published in:Scientific reports 2017-10
Main Authors: Vila Farrés, Xavier, Parra Millán, Raquel, Sánchez Encinales, Viviana, Varese, Monica, Ayerbe Algaba, Rafael, Bayó Puxan, Núria, Guardiola, Salvador, Pachón Ibáñez, María Eugenia, Kotev, Martin, García Arroyo, Jesús, Teixidó Turà, Meritxell, Vila Estapé, Jordi, Pachón, Jerónimo, Giralt Lledó, Ernest, Smani, Younes
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacteris gramnegatius
Gram-negative bacteria
Malalties bacterianes
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Summary:Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.
ISSN:2045-2322
2045-2322