Preservative and Irritant Capacity of Biosurfactants From Different Sources: A Comparative Study

One of the most important challenges for pharmaceutical and cosmetic industries is solubilization and preservation of their active ingredients. Therefore, most of these formulations contain irritant chemical additives to improve their shelf-life and the solubility of hydrophobic ingredients. An inte...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2019-07, Vol.108 (7), p.2296-2304
Main Authors: Rodríguez-López, Lorena, Rincón-Fontán, Myriam, Vecino, Xanel, Cruz, José Manuel, Moldes, Ana Belén
Format: Article
Language:English
Subjects:
Aspergillus brasiliensis
Biosurfactant
Biosurfactants
Blat de moro
Candida albicans
Corn
Enginyeria química
Escherichia coli
Industria farmaceútica
Lactobacillus pentosus
Nonirritant
Pharmaceutical industry
Preservative
Àrees temàtiques de la UPC
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Summary:One of the most important challenges for pharmaceutical and cosmetic industries is solubilization and preservation of their active ingredients. Therefore, most of these formulations contain irritant chemical additives to improve their shelf-life and the solubility of hydrophobic ingredients. An interesting alternative to chemical surfactants and preservatives is the use of biosurfactants; thus, their surfactant properties and composition make them more biocompatible than their chemical counterparts. Moreover, some biosurfactants have shown antimicrobial activity in addition to their detergent capacity. In this work, the antimicrobial and irritant effect of 2 biosurfactant extracts was studied: one produced in a controlled fermentation process with Lactobacillus pentosus and the other produced from corn stream by spontaneous fermentation. The results showed a strong antimicrobial activity of the biosurfactant extract obtained from corn stream on pathogenic bacteria, in comparison with the L. pentosus biosurfactant extract. Moreover, both biosurfactants did not produce any irritant effect on the chorioallantoic membrane of hen's egg assay contrary to sodium dodecyl sulfate. This is the first study dealing with the application of biosurfactant extracts on sensitive biological membranes, and this is the first time that the preservative capacity of a biosurfactant extract obtained in spontaneous fermentation is being evaluated, achieving promising results.
ISSN:0022-3549
1520-6017
1520-6017
DOI:10.1016/j.xphs.2019.02.010