PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness

Phosphatase PRL-3 has been involved in different types of cancer, especially in metastases from colorectal carcinoma (CRC). In this study, we explored both isoforms of PRL-3 as a biomarker to predict the recurrence of stage IIIB-C CRC. Overexpression of PRL-3 was investigated in primary human colore...

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Published in:British journal of cancer 2008-10
Main Authors: Molleví, David Garcia, Aytés Meneses, Álvaro, Padullés Mosella, Laura, Martínez Iniesta, María, Baixeras, Núria, Salazar Soler, Ramón, Ramos Rubio, Emilio, Figueras Aloy, José, 1950, Capellá, G. (Gabriel), Villanueva Garatachea, Alberto
Format: Article
Language:English
Subjects:
Colorectal cancer
Càncer colorectal
Càncer de fetge
Liver cancer
Metabolism
Metabolisme
Pathology
Patologia
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Summary:Phosphatase PRL-3 has been involved in different types of cancer, especially in metastases from colorectal carcinoma (CRC). In this study, we explored both isoforms of PRL-3 as a biomarker to predict the recurrence of stage IIIB-C CRC. Overexpression of PRL-3 was investigated in primary human colorectal tumours (n=20) and hepatic metastases (n=36) xenografted in nude mice, samples characterised by absence of human non-tumoral cells, showing a high degree of expression in metastases (P=0.001). In 27 cases of matched normal colonic mucosa/primary tumour/hepatic metastases, PRL-3 overexpression occurs in primary tumours vs normal mucosa (P=0.001) and in hepatic metastases vs primary tumours (P=0.045). Besides, our results in a series of 80 stage IIIB-C CRC primary tumours showed that high levels of PRL-3 were an independent predictor of metastasis (P
ISSN:0007-0920