HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort

The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocardi...

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Published in:PloS one 2013-05
Main Authors: Chambers, Stephen T, Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, M. (Manel), Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M, Harkness, Jonh, Kanafani, Zeinha A, Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W, Wray, Dannah, Corey, G. Ralph, Chu, Vivian H, Sitges Carreño, Marta, Miró Meda, José M, Moreno Camacho, Ma. Asunción, Anguera Camós, Ignasi, International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
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Language:English
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Control d'infeccions
Endocarditis
Infection control
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creator Chambers, Stephen T
Murdoch, David
Morris, Arthur
Holland, David
Pappas, Paul
Almela, M. (Manel)
Fernández Hidalgo, Nuria
Almirante, Benito
Bouza, Emilio
Forno, Davide
Rio, Ana del
Hannan, Margaret M
Harkness, Jonh
Kanafani, Zeinha A
Lalani, Tahaniyat
Lang, Selwyn
Raymond, Nigel
Read, Kerry
Vinogradova, Tatiana
Woods, Christopher W
Wray, Dannah
Corey, G. Ralph
Chu, Vivian H
Sitges Carreño, Marta
Miró Meda, José M
Moreno Camacho, Ma. Asunción
Anguera Camós, Ignasi
International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
description The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p
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(Manel) ; Fernández Hidalgo, Nuria ; Almirante, Benito ; Bouza, Emilio ; Forno, Davide ; Rio, Ana del ; Hannan, Margaret M ; Harkness, Jonh ; Kanafani, Zeinha A ; Lalani, Tahaniyat ; Lang, Selwyn ; Raymond, Nigel ; Read, Kerry ; Vinogradova, Tatiana ; Woods, Christopher W ; Wray, Dannah ; Corey, G. Ralph ; Chu, Vivian H ; Sitges Carreño, Marta ; Miró Meda, José M ; Moreno Camacho, Ma. Asunción ; Anguera Camós, Ignasi ; International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators</creator><creatorcontrib>Chambers, Stephen T ; Murdoch, David ; Morris, Arthur ; Holland, David ; Pappas, Paul ; Almela, M. (Manel) ; Fernández Hidalgo, Nuria ; Almirante, Benito ; Bouza, Emilio ; Forno, Davide ; Rio, Ana del ; Hannan, Margaret M ; Harkness, Jonh ; Kanafani, Zeinha A ; Lalani, Tahaniyat ; Lang, Selwyn ; Raymond, Nigel ; Read, Kerry ; Vinogradova, Tatiana ; Woods, Christopher W ; Wray, Dannah ; Corey, G. Ralph ; Chu, Vivian H ; Sitges Carreño, Marta ; Miró Meda, José M ; Moreno Camacho, Ma. Asunción ; Anguera Camós, Ignasi ; International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators</creatorcontrib><description>The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p&lt;0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p&lt;0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p&lt;0.01) and younger age (OR 0.62; CI 0.49-0.90; p&lt;0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p&lt;0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. 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1932-6203
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subjects Control d'infeccions
Endocarditis
Infection control
title HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
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