A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance

In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to redu...

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Bibliographic Details
Published in:SAGE open medical case reports 2017, Vol.5, p.2050313X17745203
Main Authors: Howard, Brandon A, James, Olga G, Perkins, Jennifer M, Pagnanelli, Robert A, Borges-Neto, Salvador, Reiman, Robert E
Format: Article
Language:English
Subjects:
Case Report
Case reports
Thyroid cancer
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Summary:In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
ISSN:2050-313X
2050-313X
DOI:10.1177/2050313X17745203