Amidoxime functionalized chitosan for uranium sequestration in vivo

Amidoxime functionalized chitosan (AC) was recommended as a chelator for uranium sequestration in vivo in this study, and the structure-activity relationship was also explored. Compared with ZnNa3-DTPA, which was a commercial uranium mobilization drug, AC exhibited excellent biocompatibility and ura...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2022-07, Vol.239, p.113636-113636, Article 113636
Main Authors: Li, Zhiheng, Wang, Siyi, Dong, Yipu, Miao, Xiaoyao, Xiao, Bingkun, Yang, Jianyun, Zhao, Jianfeng, Huang, Rongqing
Format: Article
Language:English
Subjects:
Amidoxime
Chitosan
Sequestration
Structure-activity relationship
Uranium
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Summary:Amidoxime functionalized chitosan (AC) was recommended as a chelator for uranium sequestration in vivo in this study, and the structure-activity relationship was also explored. Compared with ZnNa3-DTPA, which was a commercial uranium mobilization drug, AC exhibited excellent biocompatibility and uranium removal efficiency, whether by injection or orally, which could reduce the amounts of uranium deposited in kidneys and femurs by up to 43.6% and 32.3%. In particular, ACs still possessed the ability to mobilize uranium in vivo even if administration was delayed for 72 h. [Display omitted] •Amidoxime functionalized chitosan (AC) exhibit excellent biocompatibility.•AC successfully reduce the concentration of uranium in vivo, whether by injection or orally.•The particle size is a crucial factor that affects the removal efficiency of uranium mobilization drug.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2022.113636