B cells: roles in physiology and pathology of pregnancy

B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet to be investigated. This review consolidates current knowledge...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2024-10, Vol.15, p.1456171
Main Authors: Liu, Jin-Chuan, Zeng, Qunxiong, Duan, Yong-Gang, Yeung, William S B, Li, Raymond H W, Ng, Ernest H Y, Cheung, Ka-Wang, Zhang, Qingqing, Chiu, Philip C N
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - immunology
B cells
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocytes - immunology
Cytokines - immunology
Cytokines - metabolism
Female
Humans
immune tolerance
Immunology
maternal-fetal interface
Pregnancy
pregnancy complications
Pregnancy Complications - immunology
Pregnancy Outcome
Signal Transduction
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet to be investigated. This review consolidates current knowledge on B cell activities and regulation during pregnancy, with a particular focus on the roles of various B cell subsets and the effects of B cell-derived factors on pregnancy outcomes. Moreover, the review examines the significance of B cell-associated autoantibodies, cytokines, and signaling pathways in relation to pregnancy complications such as pregnancy loss, preeclampsia, and preterm birth.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1456171