Potential applications of peptide nucleic acid in biomedical domain

Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo complementary binding to RNA/DNA with high affinit...

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Bibliographic Details
Published in:Engineering Reports 2020-09, Vol.2 (9), p.e12238-n/a
Main Authors: Singh, Kshitij RB, Sridevi, Parikipandla, Singh, Ravindra Pratap
Format: Article
Language:English
Subjects:
Acetic acid
Acids
Biomedical application
Biomedical materials
Biosensors
Cyanobacteria
Deoxyribonucleic acid
Diagnosis
DNA
Enzymes
Fluorescence
Genetic engineering
Human papillomavirus
Hybridization
Ions
Nucleic acids
Peptides
PNA
PNA properties
Polymerase chain reaction
Review
Ribonucleic acid
RNA
Therapeutics
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Description
Summary:Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo complementary binding to RNA/DNA with high affinity and specificity. Hence, to date, many methods utilizing PNA for diagnosis and treatment of various diseases namely cancer, AIDS, human papillomavirus, and so on, have been designed and developed. They are being used widely in polymerase chain reaction modulation/mutation, fluorescent in‐situ hybridization, and in microarray as a probe; they are also utilized in many in‐vitro and in‐vivo assays and for developing micro and nano‐sized biosensor/chip/array technologies. Earlier reviews, focused only on PNA properties, structure, and modifications related to diagnostics and therapeutics; our review emphasizes on PNA properties and synthesis along with its potential applications in diagnosis and therapeutics. Furthermore, prospects in biomedical applications of PNAs are being discussed in depth. Peptide nucleic acids are DNA/RNA synthetic analogs. They show unique stability and hybridization properties and have enormous biomedical applications for diagnostics (utilizing biosensors, microarray, and so on) and therapeutics. Hence, this review emphasizes the PNAs biomedical application along with its properties, synthesis, and prospects.
ISSN:2577-8196
2577-8196
DOI:10.1002/eng2.12238