Sepia officinalis ink mitigates gastric ulcer via modulation of antioxidant/anti-inflammatory pathways

Background Sepia officinalis ink is a bioactive secondary metabolite rich in melanin granules, which has a wide range of nutritional and therapeutic values and also has been used to prevent various gastrointestinal disorders. Gastric ulcer, the most common gastrointestinal disease, is characterized...

Full description

Saved in:
Bibliographic Details
Published in:Beni-Suef University journal of basic and applied sciences 2022-05, Vol.11 (1), p.1-12, Article 63
Main Author: Sadek, Shimaa A.
Format: Article
Language:English
Subjects:
Ethanol
Gastric ulcer
Medicine
Medicine & Public Health
Nitric oxide
Oxidative stress
Sepia officinalis ink
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Sepia officinalis ink is a bioactive secondary metabolite rich in melanin granules, which has a wide range of nutritional and therapeutic values and also has been used to prevent various gastrointestinal disorders. Gastric ulcer, the most common gastrointestinal disease, is characterized by severe gastric mucosa damage, and its prevention is currently one of the main goals of clinical and experimental studies. Thus, the present study was focused on evaluating the potential gastroprotective efficacy of Sepia officinalis ink extract (SOIE) against ethanol-induced gastric ulcer in rats. Results The current results revealed that SOIE administration at the two selected doses improved significantly gastric mucosa integrity as indicated by the significant ( P  
ISSN:2314-8543
2314-8543
DOI:10.1186/s43088-022-00242-y