Pharmacological immunomodulation enhances peripheral nerve regeneration Imunomodulação farmacológica aumenta a regeneração de nervos periféricos

To assess the effect of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine MDP topically administrated on the regenerating peripheral neurons, twelve male C57BL/6J adult mice were equally distributed into three groups. Four mice underwent unilateral sciatic nerve transection and polyethylene tubulization, with...

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Published in:Pesquisa veterinária brasileira 2007-09, Vol.27 (9), p.363-369
Main Authors: Ana Paula Inoe, Francisco Carlos Pereira, Angelo João Stopiglia, Ciro Ferreira Da-Silva
Format: Article
Language:English
Subjects:
cirurgia
drug effect
efeitos de drogas
N-acetilmuramil-L-alanil-D-isoglutamina MDP
N-Acetylmuramyl-L-Alanyl-D-Isoglutamine MDP
nerve regeneration
nervo ciático
regeneração nervosa
sciatic nerve
surgery
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Summary:To assess the effect of N-Acetylmuramyl-L-Alanyl-D-Isoglutamine MDP topically administrated on the regenerating peripheral neurons, twelve male C57BL/6J adult mice were equally distributed into three groups. Four mice underwent unilateral sciatic nerve transection and polyethylene tubulization, with a 4mm gap between the proximal and distal nerve stumps and were implanted with collagen + PBS (COL). Other four animals underwent the same surgical procedure but received collagen + MDP (COL/MDP) inside the prosthesis. Four animals were not operated and served as control group (NOR). After 4 weeks, the regenerated nerve cables were processed for total myelinated axon counting and myelinated fiber diameter measurement. The L5 dorsal root ganglion (DRG) was also removed and sectioned for sensory neurons counting and measurement. The results revealed significant difference (p
ISSN:0100-736X
1678-5150
DOI:10.1590/S0100-736X2007000900002