Changes of Urinary Cytokines in Non-Diabetic Obese Patients After Laparoscopic Sleeve Gastrectomy

Adipose tissues synthesize and secrete various proinflammatory and anti-inflammatory mediators, termed cytokines. This work aims to assess different serum and urinary cytokine levels before and 12 months after laparoscopic sleeve gastrectomy (LSG). This prospective study was performed on 61 obese no...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.825-831
Main Authors: Salman, Ahmed, Salman, Mohamed, Sarhan, Mohamed D, Maurice, Karim, Tag El-Din, Mohamed, Youssef, Ahmed, Ahmed, Reham, Abouelregal, Tarek, Shaaban, Hossam El-Din, GabAllah, Ghada M K, Omar, Mahmoud Gouda
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissues
Blood pressure
Body mass index
C-reactive protein
Cardiovascular disease
Chemokines
Creatinine
Cytokines
Diabetes
Diabetics
Enrollments
Enzymes
Gastroesophageal reflux
Gastrointestinal surgery
Hypertension
Kidney diseases
Laboratories
laparoscopic sleeve gastrectomy
Laparoscopic surgery
Laparoscopy
Ligands
Medical research
Medicine, Experimental
Metabolism
Obesity
Original Research
Patients
Sleep apnea
urinary cytokines
Urine
Weight control
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Summary:Adipose tissues synthesize and secrete various proinflammatory and anti-inflammatory mediators, termed cytokines. This work aims to assess different serum and urinary cytokine levels before and 12 months after laparoscopic sleeve gastrectomy (LSG). This prospective study was performed on 61 obese non-diabetic patients who underwent LSG. All patients were followed up postoperatively at 12 months with the assessment of arterial blood pressure, microalbuminuria, urinary and serum levels of inflammatory cytokines (macrophage migration inhibitory factor "MIF," monocyte chemotactic protein "MCP"-1, chemokine (C-C motif) ligand 15 (CCL-15), and CCL-18), in addition to serum creatinine, total cholesterol, and C-reactive protein (CRP). Mean BMI showed decreased substantially from 44.78 ± 3.59 Kg/m to 34.56 ± 2.45. Systolic blood pressure decreased from 147.03 ± 16.89 mmHg to 128.82 ± 12.52 and diastolic blood pressure decreased from 90.51 ± 12.71 mmHg to 79.69 ± 10.39. At one-year of follow-up, there was statistically significant decrease of mean serum creatinine, total cholesterol, CRP, CCL-15, CCL-18, MIF/creatinine ratio, MCP-1/creatinine ratio, CCL-15/creatinine ratio, and CCL-18/creatinine ratio (P value
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S302418