Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes

Background Aneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI‐1 for the regulation of tissue plasminogen activator is considered an important therapeutic target for aS...

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Bibliographic Details
Published in:Molecular genetics & genomic medicine 2019-08, Vol.7 (8), p.e737-n/a
Main Authors: Lin, Mingkuan, Griessenauer, Christoph J., Starke, Robert M., Tubbs, R. Shane, Shoja, Mohammadali M., Foreman, Paul M., Vyas, Nilesh A., Walters, Beverly C., Harrigan, Mark R., Hendrix, Philipp, Fisher, Winfield S., Pittet, Jean‐Francois, Mathru, Mali, Lipsky, Robert H.
Format: Article
Language:English
Subjects:
Alleles
Aneurysm
Aneurysms
Atherosclerosis
Brain damage
Brain Edema - epidemiology
Brain injury
Brain Ischemia - epidemiology
Cardiovascular disease
Case-Control Studies
Clinical outcomes
clinical vasospasm
Coma
Consent
Delayed Cerebral Ischemia
Edema
Extracellular matrix
Gene expression
Gene polymorphism
Genetic Predisposition to Disease - genetics
Genotype
Genotyping
Glasgow Coma Scale
Haplotypes
Heart attacks
Hemorrhage
Homozygotes
Humans
Hypertension
Incidence
Ischemia
Mortality
Odds Ratio
Original
Patients
Permutations
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism
Polymorphism, Single Nucleotide
Risk analysis
SERPINE1
Single-nucleotide polymorphism
Statistical analysis
Statistical methods
Studies
Subarachnoid Hemorrhage
Subarachnoid Hemorrhage - epidemiology
Subarachnoid Hemorrhage - genetics
t-Plasminogen activator
Therapeutic applications
Tissue Plasminogen Activator
Vasoconstriction
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Summary:Background Aneurysmal subarachnoid hemorrhage (aSAH) has high fatality and permanent disability rates due to the severe damage to brain cells and inflammation. The SERPINE1 gene that encodes PAI‐1 for the regulation of tissue plasminogen activator is considered an important therapeutic target for aSAH. Methods Six SNPs in the SERPINE1 gene (in order of rs2227631, rs1799889, rs6092, rs6090, rs2227684, rs7242) were investigated. Blood samples were genotyped with Taqman genotyping assays and pyrosequencing. The experiment‐wide statistically significant threshold for single marker analysis was set at p 
ISSN:2324-9269
2324-9269
DOI:10.1002/mgg3.737